Sinus Doctors and Researchers from all over the world gathered in Vienna last week for the annual meeting European Association of Allergy and Immunology (EAACI) to present new studies and discuss how these findings integrated into our understanding of sinus disease.
Emerging topics of interest included the importance of dysfunction in the mucosal barrier in the development of CRS, treatment of CRS with monoclonal antibody’s, and the role of the microbiome in the development of CRS disease and implications for therapy.
Researchers from Belgium and the United States describe how, in CRS and then allergy, the sinus epithelium (the superficial layer of the sinus mucosa in contact with the outside world) was “leaky” and allow both loss of fluid from the internal environment into the sinus, and also facilitated the penetration of bacteria or allergens deep underneath the skin lining. In addition, they suggested that mechanisms such as autoimmune disorders may contribute to epithelial loss, leading to CRS.
Evidence supports the potential interest of using monoclonal antibody’s for the treatment of CRS. In placebo-controlled trials of dupilimab in CRS patients, the author showed that treatment significantly improved quality of life of infected patients. This suggests new drugs and new treatment strategies will be available in coming years for patients with chronic sinusitis.
Lastly, Dr. Martin Desrosiers from Montreal presented an invited lecture on the role of the microbiome in chronic sinusitis. Ducted roseate illustrated how changes in the bacterial population of the sinuses change following surgery, and how this might be harnessed for new treatments and better results in the future.
Prepared by: Martin Desrosiers, MD, Clinical Professor, Université de Montréal
Disclaimer: This post and website provides general information only. It does not provide medical advice nor is it a substitute for the advice of a physician. Patients are advised to always consult their physician for any specific information about their personal health. This web site does not intend to create a doctor-patient relationship. There will be no provision of or undertaking to provide, care or advice by a physician through the use of this web site.